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Nexus is the official publication of the biennial German Jewish Studies Workshop, which was inaugurated at Duke University in 2009, and is now held at the University of Notre Dame. Together, Nexus and the Workshop constitute the first ongoing forum in North America for German Jewish Studies. Nexus publishes innovative research in German Jewish Studies, introducing new directions, analyzing the development and definition of the field, and considering its place vis-à-vis both German Studies and Jewish Studies. Additionally, it examines issues of pedagogy and programming at the undergraduate, graduate, and community levels. Nexus 3 features special forum sections on Heinrich Heine and Karl Kraus. Renowned Heine scholar Jeffrey Sammons offers a magisterial critical retrospective on this towering "German Jewish" author, followed by a response from Ritchie Robertson, while the dean of Kraus scholarship, Edward Timms, reflects on the challenges and rewards oftranslating German Jewish dialect into English. Paul Reitter provides a thoughtful response.
Contributors: Angela Botelho, Jay Geller, Abigail Gillman, Jeffrey A. Grossman, Leo Lensing, Georg Mein, Paul Reitter, Ritchie Robertson, Jeffrey L. Sammons, Egon Schwarz, Edward Timms, Liliane Weissberg, Emma Woelk.
William Collins Donahue is the John J. Cavanaugh Professor of the Humanities at the University of Notre Dame, where he chairs the Department of German and Russian. Martha B. Helfer is Professor of German and an affiliate member of the Department of Jewish Studies at Rutgers, The State University of New Jersey.
Chagas’ disease is a neglected tropical disease caused by Trypanosoma cruzi and constitutes a serious public health problem for Latin America. Its unsatisfactory chemotherapy stimulates the search for novel antiparasitic compounds. Amidines and related compounds exhibit well-known activity towards different microbes including T. cruzi. In this vein, our present aim was to evaluate the biological effect of 10 novel structurally related amidines in vitro against bloodstream and intracellular forms of the parasite as well as their potential toxicity on cardiac cell cultures. Our results show that although active against the extracellular forms, with some of them like DB2247 being 6-fold more effective than benznidazole and displaying very low toxicity (>96 μm), none presented superior trypanocidal effect against intracellular forms as compared with the reference drug. These results may be due to differences in susceptibility profiles related to distinct uptake/extrusion mechanisms and cellular targets between bloodstream and amastigote forms. The present study adds to the knowledge base for the future design of novel amidines that may provide promising activity against T. cruzi.
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